
DubbelHelix (2011–2015) — cancer patient community portal and biomarker company. Stanford-licensed TGS diagnostic. Predecessor to Syncofy LLC.
The Science

~7,000 addressable DLBCL cases/year in US alone. 7-market total projected at 140K by 2019. Underpinned pharma outreach to Pfizer, Sanofi, Rinat, Immungene.
The TGS assay ran on standard clinical pathology infrastructure — FFPE blocks already collected for diagnosis, no additional biopsy. The two-gene signature (LMO2 high + CD137 low = poor prognosis) stratified DLBCL patients into risk tiers actionable for trial enrollment and treatment selection.
Timeline
Cancer patient community portal launched at dubbelhelix.com — forums for Brain Tumor, Breast Cancer, Leukemia, and Non-Hodgkins Lymphoma patients, care givers, and advocates. Tagline: "A Patient's Laboratory."
Exclusive license application for the Two Gene Score (TGS) biomarker — LMO2 + CD137/4-1BB measured by rt-PCR in FFPE tissue — for DLBCL prognosis. Patent 7,711,492.
TGS validation data presented at ASH. NHL market analysis: 7-market model, ~7,000 cases/year addressable for diagnostic test. Pharma outreach to Pfizer, Sanofi, Rinat, Immungene.
B2B/pharma-facing successor entity, accepted into the first StartX Med class (Stanford's healthcare accelerator). Founding team: Holbrook Kohrt MD PhD (Stanford immunologist, NK cell/ADCC pioneer), Russell Pachynski MD (Stanford/WashU hematology-oncology), and Jason Yonehiro (biotech entrepreneur). Combined Stanford licenses S10-292 (TGS) + S04-183. NCI CDA executed.
KOL intelligence infrastructure for pharma commercial teams. The data science approach from TGS — systematic measurement replacing expert opinion — applied to physician influence at scale.
CombImmune Founding Team
Oncologist-immunologist and Stanford Assistant Professor, trained under Ron Levy in the Levy Lab on Lymphocytes and Lymphoma. Launched his independent lab in 2012. Died February 2016, age 38, from complications of severe hemophilia.
Kohrt established the mechanistic rationale for combining NK checkpoint release (anti-KIR) with tumor-targeting antibodies — a concept now embedded in multiple active clinical programs. His dual PhD in biostatistics and tumor immunology made him equally rigorous in trial design and bench science. At the time of his death, five novel patented immuno-oncology approaches were in active development.
Tributes: The Lancet · Clinical Cancer Research (AACR) · Blood/ASH Clinical News · PMC5084977
Immunologist and Associate Professor of Medicine at WashU, where he serves as GU Oncology Research Director at the Siteman Cancer Center. Joined WashU faculty in 2014. ACS Research Scholar and Harrington Discovery Institute Scholar.
His core discovery: chemerin — an endogenous chemoattractant — is systematically down-regulated across tumor types. Restoring chemerin drives pDC, CD8+ T cell, and NK cell infiltration into the tumor microenvironment, suppressing tumor growth through immune surveillance and trafficking. This mechanism underpins both the original CombImmune thesis and his current work at Pixie BioSciences.

Chemerin drives pDC, CD8+ T cell, and NK cell infiltration into the tumor microenvironment vs. control (* p<0.05). Source: Pachynski lab / CombImmune.
Biotech entrepreneur. Holder of Stanford TGS license S10-292. Led operations, business development, and NCI CDA execution for DubbelHelix and CombImmune. Built the pharma outreach pipeline (Pfizer, Sanofi, Rinat, Immungene) and ASH market analysis. DubbelHelix → CombImmune → Syncofy LLC.
The Patient Portal (2011–2012)
DubbelHelix.com ran cancer-specific forums where patients, care givers, and advocates could ask questions anonymously and connect with others navigating the same diagnosis. The platform had separate boards for Brain Tumor, Breast Cancer, Leukemia, and Non-Hodgkins Lymphoma, with a real-time health news feed aggregating ASCO, ASH, and American Cancer Society releases.

The original DubbelHelix patient portal brochure distributed in 2012. Tagline: "Whether they be care takers, cancer advocates or real cancer survivors, this web portal is the perfect destination for anonymous discussion about questions you may have about cancer."
dubbelhelix.com · 2012
Active since 2011 · Facebook archive (2011–2015)
Site Archive — 2011–2012
Screenshots from the original DubbelHelix.com patient portal, captured during active operation. Forums, community boards, and the homepage as they appeared to patients and caregivers.
DubbelHelix → CombImmune → Syncofy
The core insight from DubbelHelix — that systematic measurement of biological signal outperforms clinical intuition for stratifying patients — translates directly to what Syncofy does for KOL identification. Replace "which DLBCL patients are high-risk?" with "which physicians are actually driving clinical practice change?" and the methodology is the same: score against raw data, not reputation networks.





